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Co-Investigator at University Hospitals Cleveland Medical Center: Clot Lysis Evaluating Accelerator Resolution of Intraventricular Hemorrhage Phase III (NIH Protocol CLEAR), Johns Hopkins Medical Center/NIH. June, 2010 � June, 2015.

Internal Advisory Board Member at University Hospitals Case Medical Center: Ohio Brain Tumor SPORE. National Institutes of Health, 2015. 

Co-Investigator at University Hospitals Case Medical Center: Biomarker & Phase II study of GDC-0449 for recurrent GBM. ARRA ACTNOW/National Institutes of Health, 2010 � 2013.

Site PI at University Hospitals Case Medical Center:  Carotid Occlusion Surgery Study (COSS). University of North Carolina/National Institutes of Health (NINDS), December, 2007 - November, 2012. ($20,150.00)

Principal Investigator at University Hospitals Case Medical Center: Study of Neuroprotective and Neurogenerative Effects of Amphetamine or Methamphetamine/CART from the NIH/NIDA, March, 2010 � February, 2012. ($72,000.00)

Co-Investigator at University Hospitals Case Medical Center: Intraoperative Stereotactic CT-guided Endoscopic Surgery â€� ICES (NIH/NINDS Protocol MISTIES-ICES).  Johns Hopkins Medical Center/NIH.  June, 2009- 2011.

Co-Investigator at University Hospitals Case Medical Center: Interventional Management of Stroke III (IMSIII).  University of Cincinnati/National Institutes of Health, 2006 â€� 2010.

Co-investigator at University Hospitals Case Medical Center: Double-blind, randomized, placebo-controlled study to assess efficacy and safety of clazosentan to reduce vasospasm-related and all-cause mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by surgical clipping (Conscious-2), Actelion.  2009 â€� 2010.

Co-Investigator at University Hospitals Case Medical Center: The Cancer Genome 365betÌåÓýÔÚÏßÊÀ½ç±­las (TCGA). SAIC Frederick Inc/National Cancer Institute, 2008 â€� 2010.

Principal Investigator at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center: Carotid Occlusion Surgery Study - NS 42167 (COSS).  National Institutes of Health, Washington University, July 1, 2001 - 2010.

Clinical Consultant for Cleveland Medical Devices, Inc., “Untethered Home Therapy System� (Grant #1-R43-NS046976-01A1), NIH/NINDS, August 15, 2004 through August 15, 2005.

Co-Principal Investigator at University Hospitals of Cleveland, “An Open-Label, Randomized, Parallel Group Study to Confirm the Safety and Efficacy of PROCRIT® (Epoetin Alfa) Administered Perioperatively vs. the Standard of Care in Blood Conservation in Subjects Undergoing Major Elective Spinal Surgery (Protocol #PR97-19-002)â€�.  OrthoBiotech Corporation, September 1, 2003 through August 31, 2005. 

Co-Investigator at University Hospitals of Cleveland, “A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Concentration of Repinotan in Patients with Acute Ischemic Stroke.â€�  Bayer Corporation, December 1, 2001 through November 30, 2005. 

Co-Investigator at Case Western Reserve University School of Medicine and University Hospitals of Cleveland, “Subarachnoid Hemorrhage â€� Mortality and Management Before and After Published Guidelines.â€�  American Heart Association Research Award, July 1, 2002 thru June 30, 2003.

Principal Investigator at University Hospitals of Cleveland, “Use of a Venous Catheter for Core Cooling and Rewarming for Temperature Control During Aneurysm Surgery (TCAS).� Innercool Therapies, Inc., July 1, 2000 through December 31, 2002.

Co-Investigator at Case Western Reserve University School of Medicine, “Fetal Hypoxia and Nicotine Exposure and Neonatal Dysfunction.â€�  Philip Morris External Research Program, May 1, 2001 through April 30, 2004.

Co-Investigator at University Hospitals of Cleveland, NIH, University of Cincinnati, “Interventional Management of Stroke.â€�  April 1, 2001 through March 31, 2003.

Co-Investigator at University Hospitals of Cleveland, NINDS, “Hemicraniectomy and Durotomy Upon Deterioration for Massive Hemispheric Infarcts, A Multicenter Prospective Randomized Study (HEADFIRST).â€�  Pilot Clinical Trial awarded funding from October 1999 through September 2002.

Primary Investigator, National Institutes of Health, “Alzheimer Proteins during Brain Metabolic Stress.â€�  #RO1 NS34731, September 30, 1997 through May 31, 2002. 

Co-Investigator, American Heart Association, “Mitochondrial Function in Ischemic Injury in Cortical Neurons.â€�  July 1, 1996 through June 30, 1998.

Co-Investigator, National Institutes of Health, “Focal Stroke:  Metabolism and pH Using Neutral Red.â€�  #2 RO1 NS22571-04A1, March 1, 1995 through February 28, 1998.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, McMasters University,  “ASA and Carotid Endarterectomy,â€� (WM82434).  July 18, 1994 through March 31, 1998.

Research Mentor to Anthony G. Alastra, Case Western Reserve University, University Hospitals of Cleveland, Howard Hughes Medical Institute, “Pathophysiology of Reversible Focal Ischemia:  Salvaging the Penumbra.â€�  June 1, 1994 through May 31, 1995.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, National Institutes of Health, “North American Symptomatic Carotid Endarterectomy Trial.â€�  #RO1 NS24456, September 1, 1992 through August 31, 1997.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, The Upjohn Company/University of Virginia, “Efficacy/Safety Study of Tirilizad Mesylate (U-74, 006F) in Patients with Subarachnoid Hemorrhage.â€�  September 1, 1992 through November 15, 1993.

Primary Investigator, National Institutes of Health, First Award, “Reversible Focal Cerebral Ischemia.â€�  #NEUA-1-R29, September 1, 1989 through August 31, 1994.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “New Model of Focal Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage in the Rat.â€�  #4677, July 1, 1989 through June 30, 1990.

Primary Investigator, Case Western Reserve University Research Initiation Grant, “Subarachnoid Hemorrhage—Rat Model.â€�  May 1, 1987 through April 30, 1988.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.â€�  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, Young Clinician Investigator Award, Research Foundation of the Association of Neurological Surgeons, “Metabolic Analysis of Focal Cerebral Ischemia.â€�  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, Case Western Reserve University Biomedical Research Support Grant Program, “Metabolic Analysis of Focal Cerebral Ischemia.â€�  #RR-05410-24, November 1, 1985 through March 31, 1986.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.â€�  #4480, July 1, 1985 through January 30, 1986.