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I primarily focus on calcium homeostasis, electrophysiology, ion channels, modulation, optical methods for measuring Ca2+, and modeling. 

Davi Friel's Biography 

The primary research objective in our lab is to uncover novel fundamental mechanisms underlying gene expression in cancers. We employ a range of advanced multi-omics technologies to comprehensively detail the oncogenic mechanisms of transcription factors and identify therapeutic targets for treatment.

Yuan Gao's Biography 

My research areas include regulation of renal ion transport, hemodynamics and cell signaling, and their roles in blood pressure control. In particular we are now investigating how dietary fructose changes kidney metabolism and thuis ion trasport in the proximal nephron and how the mechanical stimulus of urine flow is transduced into chemical signals that ultimately alter Na reabsorption in thick ascending limbs.

We study the intersection between metabolism, chromatin, and gene regulation. We aim to discover how metabolite signaling to chromatin impacts cell and tissue function in health and disease, with a particular focus on the intestine. We use biochemical techniques, cell culture and organoid systems, and animal models to carry out our research. 

Leah A. Gates's Biography

Mucin type O-glycosylation is an essential post translational protein modification linked to multiple disease states including many cancers and is critical to development.  Our lab studies the control of mucin type O-glycosylation at the transferase and peptide acceptor substrate level.  We utilize enzyme activity/kinetics and structural biological approaches to deduce how the initiating glycosyltransferases select and recognize specific sites to glycosylate in protein substrates.  

Thomas A. Gerken's Biography 

We investigate transgenic mice and carcinogenesis, retroviral gene therapy, DNA repair, hematopoietic stem cells, and adipogenesis. 

Stanton Gerson's Biography 

My lab investigates fungal pathogens including Candida, Aspergillus and Cryptococcus, in addition to fungal virulence factors including phospholipase B, germination, adhesion, and biofilm formation. 

Mahmoud Ghannoum's Biography

I research the physiology of vision at the molecular level and lipid metabolism and homeostasis in the eye. I also design therapeutic strategies against age-related retinal degeneration and dry eye syndrome. 

Marcin Golczak's Biography 

We are interested in mechanisms by which endocrine hormones influence the immune response. Receptors for steroid hormones (estrogens, androgens, and progesterone) are broadly expressed and regulate gene transcription in target cells. We study how these pathways operate in immune cells, particularly how they contribute to the balance between immune homeostasis and chronic inflammation & autoimmunity.

Wendy A. Goodman's Biography 

The massively complex human genome is a super-computer that carefully controls its information. It uses chemical-genetic circuits, 3D folding, and signal integration to maintain cell identity and all biological functions. Our lab is excited to unravel the principles of the super-computer we call the epigenome, and do so in the context of cancer.

Berkley Gryder's Biography